Motilium alternatives: what to try when domperidone isn’t right for you

If Motilium (domperidone) isn’t available or you’re worried about its side effects, you’ve got options. Below I outline common prescription substitutes, over‑the‑counter picks, and lifestyle fixes that can actually help with nausea, bloating, and slow gastric emptying. Use this as a quick guide to talk with your doctor or pharmacist.

Prescription alternatives

Metoclopramide (Reglan) is a common swap. It speeds up stomach emptying and helps nausea, but it can cause fatigue, restlessness, or, with long use, movement problems (tardive dyskinesia). Doctors usually limit how long you take it.

Ondansetron (Zofran) is an anti‑nausea drug often used for vomiting. It doesn’t improve stomach motility like domperidone, but it’s great for preventing nausea after surgery or chemotherapy. Note: ondansetron can affect heart rhythm in some people, so mention any heart meds.

Erythromycin at low doses can act as a prokinetic and speed digestion. It’s used short term because of antibiotic resistance and possible interactions with other drugs. It can also affect heart rhythm in some cases.

Levosulpiride or itopride are prokinetics used in some countries. They work on dopamine receptors like domperidone but availability varies by region and some have psychiatric side effects. Your doctor can tell you which of these makes sense where you live.

OTC, natural, and lifestyle options

For mild symptoms, try ginger (tea, chews, or supplements). Many people find ginger eases nausea without prescription drugs. Peppermint can help bloating and gas—peppermint oil capsules work well for some types of indigestion.

Small, frequent meals and avoiding fatty or very spicy foods reduces fullness and slow digestion. Eating slowly, avoiding carbonated drinks, and staying upright for an hour after eating often helps too.

If constipation is part of the problem, a gentle laxative or a fiber change can improve overall stomach emptying. Ask your provider before starting a new supplement, especially if you take other meds.

Before switching meds, check a few things with your clinician: any heart conditions or medications that affect heart rhythm (many antiemetics can do this), a history of movement disorders, and any other drugs that could interact. Don’t stop prescription meds suddenly without advice.

If symptoms are severe—weight loss, frequent vomiting, or signs of dehydration—seek prompt medical attention. For chronic issues, your doctor may recommend tests (like gastric emptying studies) to target the right treatment.

Want help comparing options for your specific case? Talk to your pharmacist or book a visit with your doctor. They can weigh risks, availability, and what’s best for your daily life.